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Article

Elevated serum circulating cell-free mitochondrial DNA in amyotrophic lateral sclerosis.

European journal of neurology - 1 Dec 2024

Li Jieyu, Gao Chao, Wang Qingqing, Liu Jing, Xie Zhiying, Zhao Yawen, Yu Meng, Zheng Yiming, Lv He, Zhang Wei, Yuan Yun, Meng Lingchao, Deng Jianwen, Wang Zhaoxia

Abstract excerpt

BACKGROUND AND PURPOSE: The substantial role of inflammation in amyotrophic lateral sclerosis (ALS) is gaining support from recent research. Studies indicate that circulating cell-free mitochondrial DNA (ccf-mtDNA) can activate the immune system and is associated with neurodegenerative diseases. This research was designed to quantify ccf-mtDNA levels in the serum of ALS patients. METHODS: The medical records of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39324867
DOI: 10.1111/ene.16493
PMCID: PMC11554856

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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