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Article

Regulation of proton partitioning in kinase-activating acute myeloid leukemia and its therapeutic implication.

Leukemia - 1 Aug 2022

Man Cheuk-Him, Zeng Xiaoyuan, Lam Wing, Ng Timothy C C, Kwok Tsz-Ho, Dang Kenny C C, Leung Thomas W Y, Ng Nelson K L, Lam Stephen S Y, Cher Chae-Yin, Leung Anskar Y H

Abstract excerpt

Gain-of-function kinase mutations are common in AML and usually portend an inferior prognosis. We reported a novel mechanism whereby kinase mutants induced intracellular alkalization characteristic in oncogenesis. Thirteen kinases were found to activate sodium/hydrogen exchanger (NHE1) in normal hematopoietic progenitors, of which FLT3-ITD, KRASG12D, and BTK phosphorylated NHE1 maintained alkaline intracellular...

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Identifiers

PMID: 35624145
DOI: 10.1038/s41375-022-01606-0
PMCID: PMC9343251

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