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Article

Effect of DNA methylation status on first-line anti-epidermal growth factor receptor treatment in patients with metastatic colorectal cancer.

International journal of colorectal disease - 1 Jun 2022

Osumi Hiroki, Ouchi Kota, Shinozaki Eiji, Takahashi Shin, Ooki Akira, Nakayama Izuma, Wakatsuki Takeru, Ogura Mariko, Takahari Daisuke, Chin Keisho, Yamaguchi Kensei, Ishioka Chikashi

Abstract excerpt

PURPOSE: The CpG island methylator phenotype (CIMP), important for carcinogenesis, is a predictor of prognosis and chemotherapy sensitivity in colorectal cancer (CRC). However, there is a lack of consensus on CIMP markers, and thus, more comprehensive methylation markers are required to reliably predict the clinical outcomes. This study aimed to clarify the effects of genome-wide DNA methylation status on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35612620
DOI: 10.1007/s00384-022-04177-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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