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Article

Association of CpG island methylator phenotype and EREG/AREG methylation and expression in colorectal cancer.

British journal of cancer - 14 Jun 2016

Lee Michael S, McGuffey Elizabeth J, Morris Jeffrey S, Manyam Ganiraju, Baladandayuthapani Veerabahdran, Wei Wei, Morris Van K, Overman Michael J, Maru Dipen M, Jiang Zhi-Qin, Hamilton Stanley R, Kopetz Scott

Abstract excerpt

BACKGROUND: High EREG and AREG expression, and left-sided primary tumours are associated with superior efficacy of anti-epidermal growth factor receptor (EGFR) therapy in metastatic colorectal cancer (CRC), but a unifying explanation of these findings is lacking. METHODS: RNA-seq, gene expression arrays, and DNA methylation profiling were completed on 179 CRC tumours. Results were validated using independent The...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27272216
DOI: 10.1038/bjc.2016.87
PMCID: PMC4984478

Genes

EREG
AREG
EGFR
BRAF
NRAS
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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