Article
Genomic Landscape of Primary Mediastinal B-Cell Lymphoma Cell Lines.
PloS one - 1 Jan 2015
Dai Haiping, Ehrentraut Stefan, Nagel Stefan, Eberth Sonja, Pommerenke Claudia, Dirks Wilhelm G, Geffers Robert, Kalavalapalli Srilaxmi, Kaufmann Maren, Meyer Corrina, Faehnrich Silke, Chen Suning, Drexler Hans G, MacLeod Roderick A F
Abstract excerpt
Primary mediastinal B-Cell lymphoma (PMBL) is a recently defined entity comprising ~2-10% non-Hodgkin lymphomas (NHL). Unlike most NHL subtypes, PMBL lacks recurrent gene rearrangements to serve as biomarkers or betray target genes. While druggable, late chemotherapeutic complications warrant the search for new targets and models. Well characterized tumor cell lines provide unlimited material to serve as...
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