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Article

Therapeutic reversal of prenatal pontine ID1 signaling in DIPG

2021-05-11

Abstract excerpt

Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive brain tumor with rare survival beyond two years. This poor prognosis is largely due to the tumor’s highly infiltrative and invasive nature. Previous reports demonstrate upregulation of the transcription factor ID1 with H3K27M and ACVR1 mutations, but this has not been confirmed in human tumors or therapeutically targeted. We developed an in utero elec...

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Literature Corpus work
7e25bd53-0113-5416-b766-7dc357ca15bb
DOI
10.1101/2021.05.10.443452
Open publication

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Therapeutic reversal of prenatal pontine ID1 signaling in DIPGDOI 10.1101/2021.05.10.443452
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