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Article

Multi-Trait Genetic Analysis Reveals Clinically Interpretable Hypertension Subtypes.

Circulation. Genomic and precision medicine - 1 Aug 2022

Vaura Felix, Kim Hyunkyung, Udler Miriam S, Salomaa Veikko, Lahti Leo, Niiranen Teemu

Abstract excerpt

BACKGROUND: Hypertension comprises a heterogeneous range of phenotypes. We asked whether underlying genetic structure could explain a part of this heterogeneity. METHODS: Our study sample comprised N=198 148 FinnGen participants (56% women, mean age 58 years) and N=21 168 well-phenotyped FINRISK participants (53% women, mean age 50 years). First, we identified genetic hypertension components with an unsupervised...

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Identifiers

PMID: 35604428
DOI: 10.1161/CIRCGEN.121.003583
PMCID: PMC9558213

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