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Mutations in rhodopsin, endothelin B receptor, and CC chemokine receptor 5 in large animals: Modeling human diseases.

Progress in molecular biology and translational science - 1 Jan 2022

Ji Ren-Lei, Tao Ya-Xiong

Abstract excerpt

G protein-coupled receptors (GPCRs) are the largest family of cell membrane receptors involved in modulating almost all physiological processes by transducing extracellular signals into the cytoplasm. Dysfunctions of GPCR-regulated signaling result in diverse human diseases, making GPCRs the most popular drug targets for human medicine. Large animals share higher similarities (in physiology and metabolism) with...

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HIV Infections
Mutation
Receptor, Endothelin B
Receptors, CCR5
Receptors, G-Protein-Coupled

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35595348
DOI: 10.1016/bs.pmbts.2022.02.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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