Article

<strong>Deletion in the Bardet-Biedl Syndrome Gene <em>TTC8</em> Results in a Syndromic Retinal Degeneration in Dogs</strong>

2020-08-26

Abstract excerpt

In golden retriever dogs, a 1 bp deletion in the canine TTC8 gene has been shown to cause progressive retinal atrophy (PRA), the canine equivalent of retinitis pigmentosa. In humans, TTC8 is also implicated in Bardet-Biedl syndrome (BBS). To investigate if the affected dogs only exhibit a non-syndromic PRA or develop a syndromic ciliopathy similar to human BBS, we recruited ten affected dogs to the study. The prog...

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Literature Corpus work: 36946520-3bf9-5cfd-8f72-056ddc4ae199
DOI: 10.20944/preprints202008.0584.v1

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