The pros and cons of vertebrate animal models for functional and therapeutic research on inherited retinal dystrophies.

doi:10.1016/j.preteyeres.2015.04.004

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Article

The pros and cons of vertebrate animal models for functional and therapeutic research on inherited retinal dystrophies.

Progress in retinal and eye research - 1 Sept 2015

Slijkerman Ralph W N, Song Fei, Astuti Galuh D N, Huynen Martijn A, van Wijk Erwin, Stieger Knut, Collin Rob W J

Abstract excerpt

Over the last decade, huge progress has been made in the understanding of the molecular mechanisms underlying inherited retinal dystrophy (IRD), as well as in the development and implementation of novel therapies, especially in the field of gene therapy. The use of mutant animal models, either naturally occurring or generated by genetic modification, have contributed greatly to our knowledge on IRD. Yet, these...

Topics

Animals
Animals, Genetically Modified
Disease Models, Animal
Humans
Phenotype
Retina
Retinal Dystrophies

Source

Open in PubMed

Identifiers

PMID: 25936606
DOI: 10.1016/j.preteyeres.2015.04.004

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