Large animal models of rare genetic disorders: sheep as phenotypically relevant models of human genetic disease.

Abstract excerpt

Animals that accurately model human disease are invaluable in medical research, allowing a critical understanding of disease mechanisms, and the opportunity to evaluate the effect of therapeutic compounds in pre-clinical studies. Many types of animal models are used world-wide, with the most common being small laboratory animals, such as mice. However, rodents often do not faithfully replicate human disease,...

Topics

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• Disease Models, Animal
• High-Throughput Nucleotide Sequencing
• Phenotype
• Rare Diseases
• Sheep