Article

Endothelin B Receptor Mutant Exhibits Craniofacial Dysmorphology Resembling Domestication Syndrome

2021-07-09

Abstract excerpt

<h4>Background: </h4> ET B -/- mutation is a major cause of HSCR, a neurocristopathy known for its enteric nervous system failure. Other than regulating ENCC migration, ET B mediates ET-1 clearance. Consequently, ET B may indirectly affect ET-1/ET A signaling, which controls CNCC migration and craniofacial development. Interestingly, it was hypothesized that “domestication syndrome” arise from changes in neural cr...

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Literature Corpus work: f069a8d4-2f03-5cb4-b116-4752741ff369
DOI: 10.21203/rs.3.rs-685151/v1

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