The carriage of the type 1 diabetes-associated R262W variant of human LNK correlates with increased proliferation of peripheral blood monocytes in diabetic patients.

doi:10.1111/j.1399-5448.2010.00656.x

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Article

The carriage of the type 1 diabetes-associated R262W variant of human LNK correlates with increased proliferation of peripheral blood monocytes in diabetic patients.

Pediatric diabetes - 1 Mar 2011

Lavrikova Elena Y, Nikitin Alexey G, Kuraeva Tamara L, Peterkova Valentina A, Tsitlidze Nina M, Chistiakov Dimitry A, Nosikov Valery V

Abstract excerpt

OBJECTIVE: Lymphocyte adaptor protein (LNK) plays a pivotal role as a suppressor of T-cell receptor-mediated immune signaling and negative regulator of lymphopoiesis and early hematopoiesis. Recently, association between the R262W (c.784T>C) variant of the SH2B3 gene (rs3184504) encoding human LNK and type 1 diabetes (T1D) was found in several populations. In this study, we aimed to check whether this marker is...

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PMID: 20546165
DOI: 10.1111/j.1399-5448.2010.00656.x

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