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Article

The Role of AKR1B1 in Diabetic Nephropathy: A Genetic Association Study and Meta-Analysis.

Genes - 31 May 2026

Tziastoudi Maria, Cholevas Christos, Dardiotis Efthimios, Tsironi Evangelia E, Divani Maria, Eleftheriadis Theodoros, Stefanidis Ioannis

Abstract excerpt

BACKGROUND: Diabetic nephropathy (DN) is a major microvascular complication of diabetes mellitus with a strong genetic component. The aldo-keto reductase family 1 member B (AKR1B1) gene has been implicated in hyperglycemia-induced renal damage. This study aimed to investigate the association between AKR1B1 variants and DN through a genetic association study (GAS) and a comprehensive meta-analysis. METHODS: A...

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Identifiers

PMID: 42353810
DOI: 10.3390/genes17060652
PMCID: PMC13298859

Genes

AKR1B1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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