Article
The A allele of the rs759853 single nucleotide polymorphism in the AKR1B1 gene confers risk for diabetic kidney disease in patients with type 2 diabetes from a Brazilian population.
Archives of endocrinology and metabolism - 8 Mar 2022
Dieter Cristine, Lemos Natália Emerim, de Faria Corrêa Nathalia Rodrigues, Pellenz Felipe Mateus, Canani Luís Henrique, Crispim Daisy, Bauer Andrea Carla
Abstract excerpt
OBJECTIVE: The AKR1B1 gene encodes an enzyme that catalyzes the reduction of glucose into sorbitol. Chronic hyperglycemia in patients with diabetes mellitus (DM) leads to increased AKR1B1 affinity for glucose and, consequently, sorbitol accumulation. Elevated sorbitol increases oxidative stress, which is one of the main pathways related to chronic complications of diabetes, including diabetic kidney disease...
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