Article
Genetic factors in chronic pancreatitis; implications for diagnosis, management and prognosis.
Best practice & research. Clinical gastroenterology - 1 Jun 2010
Derikx Monique H M, Drenth Joost P H
Abstract excerpt
Chronic pancreatitis (CP) is a clinical situation with persisting inflammation leading to destruction of the pancreas ensuing endocrine and exocrine failure. There are 4 subtypes: hereditary, idiopathic, alcoholic and tropical pancreatitis. Genetic factors can explain a significant proportion of CP cases. The PRSS1 gene, encoding cationic trypsinogen, was found to be correlated with hereditary CP. This signalled...
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