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Intratumoural pks Escherichia coli is associated with risk of metachronous colorectal cancer and adenoma development in people with Lynch syndrome

1 Apr 2025

Abstract excerpt

Background The adverse gut microbiome may underlie the variability in risks of colorectal cancer (CRC) and metachronous CRC in people with Lynch syndrome (LS). The role of pks +/− Escherichia coli ( pks +/− E. coli ), Enterotoxigenic Bacteroides fragilis (ETBF), and Fusobacterium nucleatum ( Fn ) in CRCs and adenomas in people with LS is unknown. Methods A total of 358 LS cases, including 386 CRCs, 90 adenomas,...

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PMID: 40158390
DOI: 10.1016/j.ebiom.2025.105661

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