Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Luteinizing Hormone Receptor Mutation (LHRN316S) Causes Abnormal Follicular Development Revealed by Follicle Single-Cell Analysis and CRISPR/Cas9.

Interdisciplinary sciences, computational life sciences - 1 Dec 2024

Zhang Chen, Nie Yongqiang, Xu Bufang, Mu Chunlan, Tian Geng G, Li Xiaoyong, Cheng Weiwei, Zhang Aijun, Li Dali, Wu Ji

Abstract excerpt

Abnormal interaction between granulosa cells and oocytes causes disordered development of ovarian follicles. However, the interactions between oocytes and cumulus granulosa cells (CGs), oocytes and mural granulosa cells (MGs), and CGs and MGs remain to be fully explored. Using single-cell RNA-sequencing (scRNA-seq), we determined the transcriptional profiles of oocytes, CGs and MGs in antral follicles. Analysis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR-Cas Systems
Share to Granulosa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infertility, Female

Share to Mice, Inbred ICR

Share to Oocytes

Share to Ovarian Follicle

Share to Receptors, LH

Share to Single-Cell Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 39150470
DOI: 10.1007/s12539-024-00646-7
PMCID: PMC11512921

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Luteinizing Hormone Receptor Mutation (LHRN316S) Causes Abnormal Follicular Development Revealed by Follicle Single-Cell Analysis and CRISPR/Cas9.PMID 39150470Read ↗

GDF9His209GlnfsTer6/S428T and GDF9Q321X/S428T bi-allelic variants caused female subfertility with defective follicle enlargementSemantic proximity Read ↗

Single-cell RNA-seq identified novel genes involved in primordial follicle formationSemantic proximity Read ↗

Application of Single-Cell RNA Sequencing in Ovarian DevelopmentSemantic proximity Read ↗

Single-cell analysis of differences in transcriptomic profiles of oocytes and cumulus cells at GV, MI, MII stages from PCOS patientsSemantic proximity Read ↗

Transcriptome Landscape of Human Oocytes and Granulosa Cells Throughout FolliculogenesisSemantic proximity Read ↗

Ligands, receptors and transcription factors that mediate inter-cellular and intra-cellular communication during ovarian follicle developmentSemantic proximity Read ↗

Single-Cell Transcriptomics Analysis of Human Small Antral FolliclesSemantic proximity Read ↗

A spatiotemporal gene expression and cell atlases of the developing rat ovarySemantic proximity Read ↗

Single-Cell Sequencing Reveals an Intrinsic Heterogeneity of the Preovulatory Follicular MicroenvironmentSemantic proximity Read ↗

Identification of miR-187 as a modulator of early oogenesis and female fecundity in medakaSemantic proximity Read ↗

Steroidogenic factor 1 (SF-1; Nr5a1 ) regulates the formation of the ovarian reserveSemantic proximity Read ↗

MATR3 is essential for oocyte growth and maturation quality through a dual molecular mechanismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.