Article
Protein and mRNA Expression in Uveal Melanoma Cell Lines Are Related to GNA and BAP1 Mutation Status.
Investigative ophthalmology & visual science - 1 Jul 2024
Gelmi Maria Chiara, de Ru Arnoud H, van Veelen Peter A, Tjokrodirijo Rayman T N, Stern Marc-Henri, Houy Alexandre, Verdijk Robert M, Vu T H Khanh, Ksander Bruce R, Vaarwater Jolanda, Kilic Emine, Brosens Erwin, Jager Martine J
Abstract excerpt
Purpose: Cell lines are being used in preclinical uveal melanoma (UM) research. Because not all cell lines harbor typical GNAQ or GNA11 hotspot mutations, we aimed at better classifying them and determining whether we could find genetic causes to explain the protein and mRNA expression profiles of the cell lines. Methods: We studied protein and mRNA expression of 14 UM cell lines and determined the presence of...
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