Article
A rare truncating mutation in ADH1C (G78Stop) shows significant association with Parkinson disease in a large international sample.
Archives of neurology - 1 Jan 2005
Buervenich Silvia, Carmine Andrea, Galter Dagmar, Shahabi Haydeh N, Johnels Bo, Holmberg Björn, Ahlberg Jarl, Nissbrandt Hans, Eerola Johanna, Hellström Olli, Tienari Pentti J, Matsuura Tohru, Ashizawa Tetsuo, Wüllner Ullrich, Klockgether Thomas, Zimprich Alexander, Gasser Thomas, Hanson Melissa, Waseem Shamaila, Singleton Andrew, McMahon Francis J, Anvret Maria, Sydow Olof, Olson Lars
Abstract excerpt
BACKGROUND: Alcohol dehydrogenases (ADHs) may be involved in the pathogenesis of neurodegenerative disorders because of their multiple roles in detoxification pathways and retinoic acid synthesis. In a previous study, significant association of an ADH class IV allele with Parkinson disease (PD) was found in a Swedish sample. PATIENTS: The previously associated single-nucleotide polymorphism plus 12 further...
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