Article
TLR9 2848 G/A Gene Polymorphism in HCV+, HIV+, and HCV+/HIV+ Individuals.
Genetic testing and molecular biomarkers - 1 May 2022
Kulmann-Leal Bruna, Ellwanger Joel Henrique, Valverde-Villegas Jacqueline María, Simon Daniel, Marangon Camila Guerra, Mattevi Vanessa Suñé, Lazzaretti Rosmeri Kuhmmer, Kuhmmer Regina, Sprinz Eduardo, Chies José Artur Bogo
Abstract excerpt
Background: Host genetic factors play a major role with respect to susceptibility to infections. Many polymorphisms of the Toll-like receptors (TLRs), members of the innate immune response, are directly associated with the clinical outcomes following infection. The 2848 G/A variant (rs352140) of the TLR9 gene is associated with increased TLR9 expression. However, the impact of the genotypes of this SNP on HIV+,...
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