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Article

Role of TLR4 Asp299Gly and Thr399Ile Gene Polymorphisms as a Risk Factor in Human Cytomegalovirus Positive Pregnant Women.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Jul 2025

Fatima Tanzeem, Syed Asad, Elgorban Abdallah M, Abid Islem, Wong Ling Shing, Khan Mohd Sajid, Khatoon Jahanarah, Singh Punit Kumar

Abstract excerpt

Human cytomegalovirus (HCMV) is the primary cause of intra-uterine infections (human health) affecting 40-100% of pregnant women globally, with lower rates observed in high-income countries and higher rates in low- and middle-income regions, and it is vertically transmitted to fetus. Mutation in the TLR4 gene is known for enhanced predisposition to several viral, bacterial, and parasitic diseases. This study...

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Identifiers

PMID: 40542308
DOI: 10.1007/s43032-025-01912-9

Genes

TLR4

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