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Human Cytomegalovirus-IE2 Affects Embryonic Liver Development and Survival in Transgenic Mouse

1 Jan 2022

Abstract excerpt

Background & Aims Congenital human cytomegalovirus (HCMV) infection is a common cause of liver injury. The major immediate-early protein 2 (IE2) of HCMV is critical for the progression of HCMV infection. As a result of species isolation, there are no animal models suitable for HCMV infection, which aimed to study the long-term effects of IE2 on embryonic liver development in vivo. Hence, this study aimed to...

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PMID: 35569816
DOI: 10.1016/j.jcmgh.2022.05.002

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