Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligase

27 Jul 2017

Abstract excerpt

Congenital human cytomegalovirus (HCMV) infection is the leading cause of neurological disabilities in children worldwide, but the mechanisms underlying these disorders are far from well-defined. HCMV infection has been shown to dysregulate the Notch signaling pathway in human neural progenitor cells (NPCs). As an important downstream effector of Notch signaling, the transcriptional regulator Hairy and Enhancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to RNA modifications and cancer
Share to Toxoplasma gondii Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28750047
DOI: 10.1371/journal.ppat.1006542

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligasePMID 28750047Read ↗

The host ubiquitin-dependent segregase VCP/p97 is required for the onset of human cytomegalovirus replicationSemantic proximity Read ↗

Human Cytomegalovirus Infection Dysregulates the Localization and Stability of NICD1 and Jag1 in Neural Progenitor CellsSemantic proximity Read ↗

Human cytomegalovirus infection perturbs neural progenitor cell fate via the expression of viral microRNAsSemantic proximity Read ↗

Human Cytomegalovirus Immediate Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the NucleusSemantic proximity Read ↗

Human Cytomegalovirus Infection Causes Degradation of Sp100 Proteins That Suppress Viral Gene ExpressionSemantic proximity Read ↗

The Human Cytomegalovirus IE1 Protein Antagonizes PML Nuclear Body-Mediated Intrinsic Immunity via the Inhibition of PML De Novo SUMOylation.Semantic proximity Read ↗

Bright and Early: Inhibiting Human Cytomegalovirus by Targeting Major Immediate-Early Gene Expression or Protein FunctionSemantic proximity Read ↗

Revisiting promyelocytic leukemia protein targeting by human cytomegalovirus immediate-early protein 1.Semantic proximity Read ↗

Downregulation of Neurodevelopmental Gene Expression in iPSC-Derived Cerebral Organoids Upon Infection by Human CytomegalovirusSemantic proximity Read ↗

Ability of the Human Cytomegalovirus IE1 Protein To Modulate Sumoylation of PML Correlates with Its Functional Activities in Transcriptional Regulation and Infectivity in Cultured Fibroblast CellsSemantic proximity Read ↗

The HUSH epigenetic repressor complex silences PML nuclear body-associated HSV-1 quiescent genomesSemantic proximity Read ↗

Human Cytomegalovirus Protein pp71 Induces Daxx SUMOylationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.