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Article

Resistance to DNA repair inhibitors in cancer.

Molecular oncology - 1 Nov 2022

Baxter Joseph S, Zatreanu Diana, Pettitt Stephen J, Lord Christopher J

Abstract excerpt

The DNA damage response (DDR) represents a complex network of proteins which detect and repair DNA damage, thereby maintaining the integrity of the genome and preventing the transmission of mutations and rearranged chromosomes to daughter cells. Faults in the DDR are a known driver and hallmark of cancer. Furthermore, inhibition of DDR enzymes can be used to treat the disease. This is exemplified by PARP...

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Identifiers

PMID: 35567571
DOI: 10.1002/1878-0261.13224
PMCID: PMC9627783

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