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Mechanism of PARP inhibitor resistance and potential overcoming strategies

24 Mar 2023

Abstract excerpt

PARP inhibitors (PARPi) are a kind of cancer therapy that targets poly (ADP-ribose) polymerase. PARPi is the first clinically approved drug to exert synthetic lethality by obstructing the DNA single-strand break repair process. Despite the significant therapeutic effect in patients with homologous recombination (HR) repair deficiency, innate and acquired resistance to PARPi is a main challenge in the clinic. In...

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PMID: 37588193
DOI: 10.1016/j.gendis.2023.02.014

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