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Targeting the DNA damage response for cancer therapy

6 Jan 2023

Abstract excerpt

The DNA damage response (DDR) is an elegant system, coordinating DNA repair with cell cycle checkpoints, that evolved to protect living organisms from the otherwise fatal levels of DNA damage inflicted by endogenous and environmental sources. Since many agents used to treat cancer; radiotherapy and cytotoxic chemotherapy, work by damaging DNA the DDR represents a mechanism of resistance. The original rational for...

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PMID: 36606678
DOI: 10.1042/bst20220681

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