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Article

Clinical approaches to overcome PARP inhibitor resistance

29 May 2025

Abstract excerpt

PARP inhibitors have profoundly changed treatment options for cancers with homologous recombination repair defects, especially those carrying BRCA1/2 mutations. However, the development of resistance to these inhibitors presents a significant clinical challenge as it limits long-term effectiveness. This review provides an overview of the current understanding of resistance mechanisms to PARP inhibitors and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40442774
DOI: 10.1186/s12943-025-02355-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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