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Article

PARP Inhibitors Resistance: Mechanisms and Perspectives

10 Mar 2022

Abstract excerpt

PolyADP-ribose polymerase (PARP) inhibitors (PARPis) represent the first clinically approved drugs able to provoke "synthetic lethality" in patients with homologous recombination-deficient (HRD) tumors. Four PARPis have just received approval for the treatment of several types of cancer. Besides, another three additional PARPis underlying the same mechanism of action are currently under investigation. Despite the...

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PMID: 35326571
DOI: 10.3390/cancers14061420

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