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Article

The Role of Epigenetics in Primary Biliary Cholangitis.

International journal of molecular sciences - 28 Apr 2022

Gerussi Alessio, Paraboschi Elvezia Maria, Cappadona Claudio, Caime Chiara, Binatti Eleonora, Cristoferi Laura, Asselta Rosanna, Invernizzi Pietro

Abstract excerpt

Primary Biliary Cholangitis (PBC) is a rare autoimmune disease of the liver, affecting mostly females. There is evidence that epigenetic changes have a pathogenic role in PBC. Epigenetic modifications are related to methylation of CpG DNA islands, post-translational modifications of histone proteins, and non-coding RNAs. In PBC, there are data showing a dysregulation of all these levels, especially in immune...

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Share to Cholangiocarcinoma and Gallbladder Cancer Studies
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenomics

Share to Genetic Predisposition to Disease

Share to Liver Cirrhosis, Biliary

Share to Liver Diseases and Immunity

Share to Pediatric Hepatobiliary Diseases and Treatments

Share to X Chromosome Inactivation

Source

Open in PubMed Open full text

Identifiers

PMID: 35563266
DOI: 10.3390/ijms23094873
PMCID: PMC9105933

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