Article
The epigenetics of PBC: The link between genetic susceptibility and environment.
Clinics and research in hepatology and gastroenterology - 1 Dec 2016
Marzorati Simona, Lleo Ana, Carbone Marco, Gershwin Merrill Eric, Invernizzi Pietro
Abstract excerpt
Primary biliary cholangitis (PBC) previously known as primary biliary cirrhosis is an autoimmune disease-associated with progressive cholestasis, the presence of autoreactive T cell and characteristic serological autoantibodies. Genetic and genome-wide association studies (GWAS) have recently shed light on the genetic background of PBC. Besides that some causal nucleotide changes and mechanisms remain largely...
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