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Article

Genetics and epigenetics in the pathogenesis of primary biliary cholangitis.

Clinical journal of gastroenterology - 1 Feb 2018

Joshita Satoru, Umemura Takeji, Tanaka Eiji, Ota Masao

Abstract excerpt

Primary biliary cholangitis (PBC) is a chronic, slowly progressive cholestatic autoimmune liver disease predominantly afflicting women. PBC is characterized by the presence of disease-specific antimitochondrial antibodies and the histological destruction of intrahepatic bile ducts, which eventually lead to cirrhosis and hepatic failure. Fortunately, ursodeoxycholic acid therapy has improved the outcome of the...

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PMID: 29159718
DOI: 10.1007/s12328-017-0799-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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