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Article

Plasma pQTL and brain eQTL integration identifies PNKP as a therapeutic target and reveals mechanistic insights into migraine pathophysiology.

The journal of headache and pain - 22 Nov 2024

Lou Jiafei, Tu Miaoqian, Xu Maosheng, Cao Zhijian, Song Wenwen

Abstract excerpt

BACKGROUND: Migraine is a prevalent neurological disorder affecting 14.1% of the global population. Despite advances in genetic research, further investigation is needed to identify therapeutic targets and better understand its mechanisms. In this study, we aimed to identify drug targets and explore the relationships between gene expression, protein levels, and migraine pathophysiology. METHODS: We utilized...

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PMID: 39578729
DOI: 10.1186/s10194-024-01922-z
PMCID: PMC11585170

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