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Article

Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache.

International journal of epidemiology - 1 Jun 2020

Siewert Katherine M, Klarin Derek, Damrauer Scott M, Chang Kyong-Mi, Tsao Philip S, Assimes Themistocles L, Davey Smith George, Voight Benjamin F

Abstract excerpt

BACKGROUND: Nearly a fifth of the world's population suffer from migraine headache, yet risk factors for this disease are poorly characterized. METHODS: To further elucidate these factors, we conducted a genetic correlation analysis using cross-trait linkage disequilibrium (LD) score regression between migraine headache and 47 traits from the UK Biobank. We then tested for possible causality between these...

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Share to Cerebrovascular and genetic disorders
Share to Circadian rhythm and melatonin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Pleiotropy

Share to Genome-Wide Association Study

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Identifiers

PMID: 32306029
DOI: 10.1093/ije/dyaa050
PMCID: PMC7394956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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