Article
Effect of non-contacted bases on the affinity of 434 operator for 434 repressor and Cro.
Nature - 1 Jan 2000
Koudelka G B, Harrison S C, Ptashne M
Abstract excerpt
The repressor of phage 434 binds to six operator sites on the phage chromosome. A comparison of the sequences of these 14-base-pair (bp) operator sites reveals a striking pattern: at five of the six sites, the symmetrically arrayed outer eight base pairs (four in each half-site) are identical and the remaining site differs at only one position (Fig. 1b). In contrast, the sequences of the inner four base pairs are...
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