DNA-based loss of specificity mutations. Effects of DNA sequence on the contacted and non-contacted base preferences of bacteriophage P22 repressor.

Article

DNA-based loss of specificity mutations. Effects of DNA sequence on the contacted and non-contacted base preferences of bacteriophage P22 repressor.

The Journal of biological chemistry - 17 Jan 1997

Hilchey S P, Koudelka G B

Abstract excerpt

Although the two central bases of the P22 operator are not contacted by the P22 repressor, changes in these bases alter the affinity of operator for repressor. Previous studies (Wu, L., and Koudelka, G. B. (1993) J. Biol. Chem. 268, 18975-18981) show that the structure of the P22 repressor-operat...

Topics

DNA
Deoxyribonuclease I
Mutation
Operator Regions, Genetic
Repressor Proteins
Viral Proteins
Viral Regulatory and Accessory Proteins

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