Article
Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility: a case-control analysis.
Breast cancer research and treatment - 1 May 2007
Huo Xiang, Hu Zhibin, Zhai Xiangjun, Wang Yan, Wang Shui, Wang Xuechen, Qin Jianwei, Chen Wenseng, Jin Guangfu, Liu Jiyong, Gao Jun, Wei Qingyi, Wang Xinru, Shen Hongbing
Abstract excerpt
The BRCA1 Associated RING Domain (BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous...
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