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Article

Crystal structure of the BARD1 ankyrin repeat domain and its functional consequences.

The Journal of biological chemistry - 25 Jul 2008

Fox David, Le Trong Isolde, Rajagopal Ponni, Brzovic Peter S, Stenkamp Ronald E, Klevit Rachel E

Abstract excerpt

BARD1 is the constitutive nuclear partner to the breast and ovarian cancer-specific tumor suppressor BRCA1. Together, they form a heterodimeric complex responsible for maintaining genomic stability through nuclear functions involving DNA damage signaling and repair, transcriptional regulation, and cell cycle control. We report the 2.0A structure of the BARD1 ankyrin repeat domain. The structure includes four...

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Share to Ankyrins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Tertiary

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Source

Open in PubMed Open full text

Identifiers

PMID: 18480049
DOI: 10.1074/jbc.M802333200
PMCID: PMC2475683

Genes

BARD1
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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