In-Silico Analyses of Nonsynonymous Variants in the BRCA1 Gene.

doi:10.1007/s10528-021-10074-7

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

In-Silico Analyses of Nonsynonymous Variants in the BRCA1 Gene.

Biochemical genetics - 1 Dec 2021

Arshad Sidra, Ishaque Irfan, Mumtaz Sidra, Rashid Muhammad Usman, Malkani Naila

Abstract excerpt

BReast CAncer gene 1 (BRCA1)-a tumor suppressor gene plays an important role in the DNA repair mechanism. Several BRCA1 variants perturb its structure and function, including synonymous and nonsynonymous single nucleotide polymorphisms (SNPs). In the present study, we performed in-silico analyses of nonsynonymous SNPs (nsSNPs) of the BRCA1 gene. In total, 122 nsSNPs were retrieved from the NCBI SNP database and...

Topics

Amino Acid Substitution
Computational Biology
Genes, BRCA1
Mutation
Polymorphism, Single Nucleotide

Source

Open in PubMed

Identifiers

PMID: 33945048
DOI: 10.1007/s10528-021-10074-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics