Article
SPERM FACTORS AND EGG ACTIVATION: The phenotype of PLCZ1-deficient mice.
Reproduction (Cambridge, England) - 23 May 2022
Satouh Yuhkoh
Abstract excerpt
In 2002, a report suggested that oocyte activation is induced by Plcz1 in mouse oocytes, which prompted great interest in exploring the role of sperm PLCZ1. Thus, PLCZ1 loss-of-function experiments became a crucial tool for addressing this subject. Although the only option to completely delete a target protein in fully functional spermatozoa is to use gene-deficient animals, Plcz1-deficient mice were not reported...
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