Article
Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP.
Human molecular genetics - 1 Mar 2016
Escoffier Jessica, Lee Hoi Chang, Yassine Sandra, Zouari Raoudha, Martinez Guillaume, Karaouzène Thomas, Coutton Charles, Kherraf Zine-Eddine, Halouani Lazhar, Triki Chema, Nef Serge, Thierry-Mieg Nicolas, Savinov Sergey N, Fissore Rafael, Ray Pierre F, Arnoult Christophe
Abstract excerpt
In mammals, sperm-oocyte fusion initiates Ca(2+) oscillations leading to a series of events called oocyte activation, which is the first stage of embryo development. Ca(2+) signaling is elicited by the delivery of an oocyte-activating factor by the sperm. A sperm-specific phospholipase C (PLCZ1) has emerged as the likely candidate to induce oocyte activation. Recently, PAWP, a sperm-born tryptophan domain-binding...
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