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Targeting tissue-resident memory CD8+ T cells in the kidney is a potential therapeutic strategy to ameliorate podocyte injury and glomerulosclerosis

5 May 2022

Abstract excerpt

Although tissue-resident-memory T (T RM ) cells, a recently identified non-circulating memory T cell population, play a crucial role in mediating local immune responses and protect against pathogens upon local reinfection, the composition, effector function, and specificity of T RM cells in the kidney and their relevance for chronic kidney disease remain unknown. In this study, we found that renal tissue...

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PMID: 35514086
DOI: 10.1016/j.ymthe.2022.04.024

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