Article
Memory T Cells in Transplantation: Old Challenges Define New Directions.
Transplantation - 1 Oct 2020
Nicosia Michael, Fairchild Robert L, Valujskikh Anna
Abstract excerpt
Immunologic memory is the ability of adaptive immune system to quickly and specifically recognize previously encountered antigens and initiate an effector response. Alloreactive memory cells can mount rapid and robust responses to the transplanted organ resulting in allograft injury. Thus preexisting humoral or cellular memory alloresponses are typically associated with poor graft outcomes in experimental and...
Topics
- Adaptive Immunity
- Animals
- Graft Rejection
- Graft Survival
- Humans
- Immunologic Memory
- Immunosuppressive Agents
- Organ Transplantation
- Phenotype
- T-Lymphocytes
- Transplantation Tolerance
- Treatment Outcome