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Article

Integrative genomic analysis reveals extended germline homozygosity with lung cancer risk in the PLCO cohort.

PloS one - 1 Jan 2012

Orloff Mohammed S, Zhang Li, Bebek Gurkan, Eng Charis

Abstract excerpt

Susceptibility to common cancers is multigenic resulting from low-to-high penetrance predisposition-factors and environmental exposure. Genomic studies suggest germline homozygosity as a novel low-penetrance factor contributing to common cancers. We hypothesized that long homozygous regions (tracts-of-homozygosity [TOH]) harbor tobacco-dependent and independent lung-cancer predisposition (or protection) genes. We...

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Identifiers

PMID: 22384118
DOI: 10.1371/journal.pone.0031975
PMCID: PMC3288062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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