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Article

A practical problem with Egger regression in Mendelian randomization.

PLoS genetics - 1 May 2022

Lin Zhaotong, Pan Isaac, Pan Wei

Abstract excerpt

Mendelian randomization (MR) is an instrumental variable (IV) method using genetic variants such as single nucleotide polymorphisms (SNPs) as IVs to disentangle the causal relationship between an exposure and an outcome. Since any causal conclusion critically depends on the three valid IV assumptions, which will likely be violated in practice, MR methods robust to the IV assumptions are greatly needed. As such a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35507585
DOI: 10.1371/journal.pgen.1010166
PMCID: PMC9109933

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