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Article

Mendelian randomization with Egger pleiotropy correction and weakly informative Bayesian priors.

International journal of epidemiology - 1 Aug 2018

Schmidt A F, Dudbridge F

Abstract excerpt

Background: The MR-Egger (MRE) estimator has been proposed to correct for directional pleiotropic effects of genetic instruments in an instrumental variable (IV) analysis. The power of this method is considerably lower than that of conventional estimators, limiting its applicability. Here we propose a novel Bayesian implementation of the MR-Egger estimator (BMRE) and explore the utility of applying weakly...

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Identifiers

PMID: 29253155
DOI: 10.1093/ije/dyx254
PMCID: PMC6124638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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