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Article

Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology.

Nature communications - 30 Jan 2018

Fujita Kyota, Chen Xigui, Homma Hidenori, Tagawa Kazuhiko, Amano Mutsuki, Saito Ayumu, Imoto Seiya, Akatsu Hiroyasu, Hashizume Yoshio, Kaibuchi Kozo, Miyano Satoru, Okazawa Hitoshi

Abstract excerpt

Mutations in the progranulin (PGRN) gene cause a tau pathology-negative and TDP43 pathology-positive form of frontotemporal lobar degeneration (FTLD-TDP). We generated a knock-in mouse harboring the R504X mutation (PGRN-KI). Phosphoproteomic analysis of this model revealed activation of signaling pathways connecting PKC and MAPK to tau prior to TDP43 aggregation and cognitive impairments, and identified PKCα as...

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Identifiers

PMID: 29382817
DOI: 10.1038/s41467-018-02821-z
PMCID: PMC5789822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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