Article
Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism.
JCI insight - 17 Nov 2016
Agbor Larry N, Ibeawuchi Stella-Rita C, Hu Chunyan, Wu Jing, Davis Deborah R, Keen Henry L, Quelle Frederick W, Sigmund Curt D
Abstract excerpt
Cullin-3 (CUL3) mutations (CUL3Δ9) were previously identified in hypertensive patients with pseudohypoaldosteronism type-II (PHAII), but the mechanism causing hypertension and whether this is driven by renal tubular or extratubular mechanisms remains unknown. We report that selective expression of CUL3Δ9 in smooth muscle acts by interfering with expression and function of endogenous CUL3, resulting in impaired...
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