Article
The clinical utility of polygenic risk scores in genomic medicine practices: a systematic review.
Human genetics - 1 Nov 2022
Kumuthini Judit, Zick Brittany, Balasopoulou Angeliki, Chalikiopoulou Constantina, Dandara Collet, El-Kamah Ghada, Findley Laura, Katsila Theodora, Li Rongling, Maceda Ebner Bon, Monye Henrietta, Rada Gabriel, Thong Meow-Keong, Wanigasekera Thilina, Kennel Hannah, Marimuthu Veeramani, Williams Marc S, Al-Mulla Fahd, Abramowicz Marc
Abstract excerpt
Genomic medicine aims to improve health using the individual genomic data of people to inform care. While clinical utility of genomic medicine in many monogenic, Mendelian disorders is amply demonstrated, clinical utility is less evident in polygenic traits, e.g., coronary artery disease or breast cancer. Polygenic risk scores (PRS) are subsets of individual genotypes designed to capture heritability of common...
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