Article
Visualized Genotyping from "Sample to Results" Within 25 Minutes by Coupling Recombinase Polymerase Amplification (RPA) With Allele-Specific Invasive Reaction Assisted Gold Nanoparticle Probes Assembling.
Journal of biomedical nanotechnology - 1 Feb 2022
Zhang Likun, Ma Xueping, Liu Danni, Shan Jingwen, Chu Yanan, Zhang Jieyu, Qi Xiemin, Huang Xiaohui, Zou Bingjie, Zhou Guohua
Abstract excerpt
A simple and rapid genotyping method with less-instrumentation is essential for realizing point-of-care detection of personalized medicine-related gene biomarkers. Herein, we developed a rapid and visualized genotyping method by coupling recombinase polymerase amplification (RPA) with allele-specific invader reaction assisted gold nanoparticle probes assembling. In the method, the DNA targets were firstly...
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